Combined QTL and selective sweep mappings with coding SNP 1 annotation and cis - eQTL analysis revealed PARK 2 and JAG 2 as
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چکیده
* INRA, UMR1348 Pegase, Saint-Gilles, 35590, France 10 § Agrocampus Ouest, UMR1348 Pegase, Rennes, 35000, France 11 † Université Européenne de Bretagne, France 12 ‡ UMR 7205 OSEB (MNHN – CNRS – EPHE – UPMC), Paris, 75005, France 13 ** INRA/AgroParisTech, UMR1313 GABI, Jouy-en-Josas, 78352, France 14 §§ Department of Medecine/Division of Cardiology, UCLA, Los Angeles, USA 15 †† UMR1331, INP, UPS, TOXALIM, INRA, Toulouse, France 16 ‡‡ INSERM, UMR 1048 I2MC, 31432 Toulouse, France 17 *** INRA, SIGENAE, Castanet-Tolosan, 31326, France 18 §§§ INRA, Plateforme GENOTOUL, Castanet-Tolosan, 31326, France 19 ††† UMR INRA, INPT ENSAT, INPT ENVT-GENPHYSE, Castanet-Tolosan, 31326, France 20 ‡‡‡ INRA, UR83 Recherches Avicoles, Nouzilly, 37380, France 21 **** Department of Human Genetics, UCLA, Los Angeles, USA 22 23 G3: Genes|Genomes|Genetics Early Online, published on February 3, 2015 as doi:10.1534/g3.115.016865
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Combined QTL and Selective Sweep Mappings with Coding SNP Annotation and cis-eQTL Analysis Revealed PARK2 and JAG2 as New Candidate Genes for Adiposity Regulation
Very few causal genes have been identified by quantitative trait loci (QTL) mapping because of the large size of QTL, and most of them were identified thanks to functional links already known with the targeted phenotype. Here, we propose to combine selection signature detection, coding SNP annotation, and cis-expression QTL analyses to identify potential causal genes underlying QTL identified i...
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